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Abstract #4343

Evaluation of Location-Dependent Attenuation of Experimental Autoimmune Encephalomyelitis after Glial-Restricted Progenitor Transplantation using CEST MRI and MRS

Aline Thomas1, Shen Li1, Chengyan Chu1, Irina Shats1, Jiadi Xu2, Peter Calabresi1, Peter van Zijl2, Piotr Walczak1, and Jeff Bulte1

1Johns Hopkins University, Baltimore, MD, United States, 2Kennedy Krieger Institute, Baltimore, MD, United States

The utility of CEST MRI and MRS as a noninvasive strategy for visualizing and tracking glial-restricted progenitor cells (GRPs) after transplantation was evaluated. GRPs increased signal in on-resonance variable delay multiple pulse (onVDMP) chemical exchange saturation transfer (CEST) MRI maps and 1H MRS at the lactate peak in cell phantoms, in naïve mice, and in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis at and/or proximal to the initial location of cells.

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