Abstract #4343

Evaluation of Location-Dependent Attenuation of Experimental Autoimmune Encephalomyelitis after Glial-Restricted Progenitor Transplantation using CEST MRI and MRS

Aline Thomas¹, Shen Li¹, Chengyan Chu¹, Irina Shats¹, Jiadi Xu², Peter Calabresi¹, Peter van Zijl², Piotr Walczak¹, and Jeff Bulte¹

¹Johns Hopkins University, Baltimore, MD, United States, ²Kennedy Krieger Institute, Baltimore, MD, United States

The utility of CEST MRI and MRS as a noninvasive strategy for visualizing and tracking glial-restricted progenitor cells (GRPs) after transplantation was evaluated. GRPs increased signal in on-resonance variable delay multiple pulse (onVDMP) chemical exchange saturation transfer (CEST) MRI maps and ¹H MRS at the lactate peak in cell phantoms, in naïve mice, and in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis at and/or proximal to the initial location of cells.

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