Abstract #4353

Statistical Assessment of Nitroxide Radicals by T1-weighted Dynamic MRI in ex-vivo Porcine Aortic wall

Mihaela Pali¹, Anja Schroeder², Franziska Veit², Sebastian Kress², Heiko Walles³, Maxim Terekhov¹, and Laura Maria Schreiber¹

¹Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, Germany, Wuerzburg, Germany, ²Chair of Tissue Engineering and Regenerative Medicine (TERM), University Hospital Wuerzburg, Germany, Chair of Tissue Engineering and Regenerative Medicine (TERM), University Hospital Wuerzburg, Germany, Wuerzburg, Germany, ³Translational Center ‘Regenerative Therapies’ (TLC-RT), Fraunhofer Institute for Silicate Research, Wuerzburg, Germany (ISC), Wuerzburg, Germany

Atherosclerosis genesis is attributed to a breakdown of homeostatic mechanisms undergoing increased oxidative stress followed by inflammation with extension to all aortic layers. Nitroxide radicals (NR) have been used as a redox-sensitive T₁ contrast agent in NMR studies. Previous results have demonstrated assessment of exogenous induce redox state by using NR. In this study, we statistically assess the kinetics of NR-induced T1-weighted contrast in the ex-vivo porcine vascular wall. The results demonstrate persistence of the key values of NR induced T₁-contrast kinetics and allow stepping further to quantitative assessment of the redox state within the vascular wall.

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