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Abstract #4379

Free-Breathing Liver T1 and Fat Mapping Using a Golden-Angle-Ordered Variable Flip Angle Stack-of-Radial Sequence

Le Zhang1, Tess Armstrong1,2, and Holden H. Wu1,2,3

1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States

Measurement of T1 and proton-density fat fraction (PDFF) in the liver can provide information about fibrosis and steatosis, respectively. Existing Cartesian acquisition schemes generally require breath-holding, which limits spatial coverage and may be difficult for sick, elderly or pediatric patients. In this study, we propose a golden-angle-ordered (GA) 3D stack-of-radial variable-flip-angle (VFA) sequence that can map T1 and PDFF simultaneously with close to full liver coverage under five minutes during free-breathing. Pilot studies in phantom and healthy subjects demonstrate feasibility and show good measurement repeatability.

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