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Abstract #4394

Quantitative Transport Mapping (QTM): a new AIF-free perfusion technique to distinguish malignant and benign breast lesions

Sarah Eskreis-Winkler1,2, Natsuko Onishi2, Liangdong Zhou3, Pascal Spincemaille1, Ramin Jafari3, Meredith Sadinski2, Elizabeth J. Sutton2, Elizabeth A. Morris2, and Yi Wang1

1Weill Cornell Medicine, New York, NY, United States, 2Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Cornell University, Ithaca, NY, United States

Quantitative perfusion imaging is challenging in the breast because the requisite arterial input function (AIF) is difficult to measure given the lack of large-caliber feeding arteries. To overcome this problem, we show that quantitative transport mapping (QTM), a new AIF-free perfusion model, is not only technically feasible in the breast, but has the potential to better distinguish malignant from benign breast lesions compared to conventional perfusion modeling.

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