Abstract #4394

Quantitative Transport Mapping (QTM): a new AIF-free perfusion technique to distinguish malignant and benign breast lesions

Sarah Eskreis-Winkler^1,2, Natsuko Onishi², Liangdong Zhou³, Pascal Spincemaille¹, Ramin Jafari³, Meredith Sadinski², Elizabeth J. Sutton², Elizabeth A. Morris², and Yi Wang¹

¹Weill Cornell Medicine, New York, NY, United States, ²Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Cornell University, Ithaca, NY, United States

Quantitative perfusion imaging is challenging in the breast because the requisite arterial input function (AIF) is difficult to measure given the lack of large-caliber feeding arteries. To overcome this problem, we show that quantitative transport mapping (QTM), a new AIF-free perfusion model, is not only technically feasible in the breast, but has the potential to better distinguish malignant from benign breast lesions compared to conventional perfusion modeling.

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