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Abstract #4397

Diagnostic performance of chemical shift in/opposed phase (IOP) and fat-fraction to evaluate the presence of intra-tumoral fat in HCC

Kritisha Rajlawot1, Jing Zhou2, Churong Lin1, Sichi Kuang1, Jingbiao Chen1, Yao Zhang1, Hao Yang1, Ying Deng1, Bingjun He1, Diego Hernando3, Jin Wang1, and Scott B Reeder3

1Department of Radiology, The third affiliated hospital of Sun Yat-sen University, Guangzhou, China, 2The third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, 3Departments of Radiology and Medical Physics, University of Wisconsin, Madison, W, University of Wisconsin, Madison, WI, Madison, WI, United States

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. Previous studies have showed that the presence of intra-tumoral fat has more favorable prognosis of HCC. We aim to compare the diagnostic accuracy of chemical shift encoded fat-fraction at three different flip angles (FA) 3°, 8° and 9°using IDEAL-IQ, in comparison to chemical shift imaging (IOP) to evaluate intra-tumoral fat in HCC.Our results showed higher positive rates of detection of intra-tumoral fat in HCC with IOP (100%) compared to IDEAL IQ at FA 3° (44.4%), FA 8° (55.6%) and FA 9° (88.9%).

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