Abstract #4403

Myelin Water Fraction Estimation using Small-Tip Fast Recovery MRI

Steven T. Whitaker¹, Gopal Nataraj², Mingjie Gao¹, Jon-Fredrik Nielsen³, and Jeffrey A. Fessler¹

¹Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, United States, ²Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States

Myelin water fraction (MWF) is a good biomarker for myelin content. Traditional methods for acquiring MWF maps require long scan times. Recent work has estimated MWF from faster steady-state scans. In this work, we propose to acquire MWF maps from an optimized set of small-tip fast recovery (STFR) scans that can exploit resonance frequency differences between myelin water and the slow-relaxing water compartment.

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