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Abstract #4403

Myelin Water Fraction Estimation using Small-Tip Fast Recovery MRI

Steven T. Whitaker1, Gopal Nataraj2, Mingjie Gao1, Jon-Fredrik Nielsen3, and Jeffrey A. Fessler1

1Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, United States, 2Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States

Myelin water fraction (MWF) is a good biomarker for myelin content. Traditional methods for acquiring MWF maps require long scan times. Recent work has estimated MWF from faster steady-state scans. In this work, we propose to acquire MWF maps from an optimized set of small-tip fast recovery (STFR) scans that can exploit resonance frequency differences between myelin water and the slow-relaxing water compartment.

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