Changes in longitudinal relaxation time (T1) and proton density (PD) are sensitive markers of microstructural damage associated with different neurological conditions including myelin degradation, axonal loss, inflammation, and edema. In this study, we propose an accurate and rapid approach to mapping T1 and PD with B1 inhomogeneity correction. This four angle method (FAM) is based on the use of four images acquired with different flip angles and short repetition times using the spoiled-gradient recalled-echo sequence available on all preclinical and clinical MRI machines. The accuracy and ease of implementation of the FAM renders it of great potential for clinical investigations.
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