Quantification of T2* relaxation time is of great interest as knowledge of it can be used for clinical diagnosis or optimisation of MR imaging parameters. A typical approach to quantify T2* is to acquire multi-echo data. Although this approach is effective, it still requires a substantial acquisition time for whole-brain coverage. This work aims to employ quantitative echo-planar imaging (QUTE-EPI) at 7T for fast and whole-brain T2* mapping. The performance of QUTE-EPI was directly compared to that of a conventional multi-echo gradient-echo sequence (MEGE). The estimated T2* values were quantitatively analysed for the regions of grey matter (GM) and white matter (WM).