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Abstract #4420

T1 Mapping at 7T Using a Novel Inversion-Recovery Look-Locker 3D-EPI Sequence

Rüdiger Stirnberg1, Yiming Dong1, Jonas Bause2,3, Philipp Ehses1, and Tony Stöcker1,4

1German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Department for Biomedical Magnetic Resonance, University of Tuebingen, Tübingen, Germany, 4Department of Physics and Astronomy, University of Bonn, Bonn, Germany

We propose a novel Inversion-Recovery Look-Locker 3D-EPI sequence for rapid T1 mapping. The inherent SNR benefit of a 3D acquisition, segmentation along both phase encode directions and a turbofactor introduced to reduce the number of required inversions can be traded freely for acquisition speed, SNR, resolution and geometric distortions. Aside from quantitative validation, two high-resolution T1 mapping applications are demonstrated at 7T: whole-brain with minimal distortions, and reduced field-of-view with geometric distortions matched to corresponding fMRI data. The results show high T1 accuracy for several turbofactor and flip angle combinations compared to a single-slice inversion-recovery 2D-EPI reference.

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