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Abstract #4518

Accuracy, repeatability, and reproducibility of longitudinal relaxation rate in twelve small-animal MR systems.

John C Waterton1,2, Catherine DG Hines3, Paul D Hockings4,5, Iina Laitinen6, Sabina Ziemian7, Simon Campbell8, Michael Gottschalk9, Claudia Green7, Michael Haase8, Katja Hoffmann6, Hans-Paul Juretschke6, Sascha Koehler10, William Lloyd1, Yanping Luo11, Irma Mahmutovic Persson9, James PB O'Connor1, Lars E Olsson9, Geoffrey JM Parker1,2, Kashmira Pindoria8, Juergen E Schneider12, Steven Sourbron12, Denise Steinmann6, Klaus Strobel10, Sirisha Tadimalla12, Irvin Teh12, Andor Veltien13, Xiaomeng Zhang11, and Gunnar Schütz7

1University of Manchester, Manchester, United Kingdom, 2Bioxydyn, Manchester, United Kingdom, 3Merck, West Point, PA, United States, 4Antaros, Mölndal, Sweden, 5Chalmers University of Technology, Gothenburg, Sweden, 6Sanofi-Aventis, Frankfurt-am-Main, Germany, 7Bayer, Berlin, Germany, 8GlaxoSmithKline, Stevenage, United Kingdom, 9Lund University, Lund, Sweden, 10Bruker, Ettlingen, Germany, 11Abbvie, North Chicago, IL, United States, 12University of Leeds, Leeds, United Kingdom, 13Radboud university medical center, Nijmegen, Netherlands

Many translational MR biomarkers derive from measurements of R1, but evidence for between-site reproducibility of R1 in small-animal MRI is lacking. Here R1 was measured by saturation-recovery in 2% agarose phantoms with five NiCl2 concentrations in 12 magnets at 5 field strengths in 11 centres on two different occasions within 1-13 days. R1 was analysed in three different regions of interest, giving 360 measurements in total. Root-mean-square repeatability and reproducibility coefficients of variation were calculated. Day-to-day repeatability was 2.3%. Between-centre reproducibility was 1.4%. Ni2+ relaxivity in 2% agarose was 0.66s-1mM-1 at 3T and 0.94s-1mM-1 at 11.7T.

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