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Abstract #4546

A robust pulse sequence for simultaneous diffusion MRI and MR elastography (diffusion-MRE)

Daiki Ito1,2,3, Tomokazu Numano1,3, Kazuyuki Mizuhara3,4, Toshikatsu Washio3, Masaki Misawa3, Naotaka Nitta3, and Tetsushi Habe1

1Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 2Office of Radiation Technology, Keio University Hospital, Tokyo, Japan, 3Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan, 4Department of Mechanical Engineering, Tokyo Denki University, Tokyo, Japan

Diffusion-magnetic resonance elastography (dMRE) can acquire diffusion and mechanical properties simultaneously. However, intravoxel phase dispersion (IVPD) interferes with the calculation of the apparent diffusion coefficient (ADC). This study presents an approach to dMRE that reduces the influence of IVPD by introducing a new pulse sequence. The ADC and stiffness, obtained using the existing and proposed dMRE techniques, were compared with spin-echo (SE)-diffusion and SE-MRE, for a phantom. In existing dMRE technique, the ADC was changed by IVPD but that of proposed dMRE technique was unchanged. The results demonstrate that our dMRE technique is a robust method for addressing the IVPD.

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