Abstract #4551

Assessment of Absolute pH Using and Magnetic Resonance Fingerprinting and a Single Dysprosium-Based MRI Contrast Agent

Yifan Zhang¹, Andre F Martins², Dean A Sherry², Christian E Anderson¹, and Chris A Flask¹

¹Radiology, Case Western Reserve University, Cleveland, OH, United States, ²Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, United States

In this initial in vitro study, we used Magnetic Resonance Fingerprinting (MRF)-based T₁ and T₂ relaxation time maps to estimate the linear relationship between pH and relaxivity (r₁ and r₂) for a previously-described dysprosium (Dy) MRI contrast agent. These relaxivity estimates were then used to calculate MRF-based estimates of pH for each solution for comparison with gold-standard measurements by pH electrode at 7.0T (R = 0.93, p = <1e-6) and 9.4T (R = 0.68, p = 0.004). Results show MRF can be used in combination with a pH-sensitive paramagnetic MRI contrast agent to accurately estimate pH independent of agent concentration.

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