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Abstract #4551

Assessment of Absolute pH Using and Magnetic Resonance Fingerprinting and a Single Dysprosium-Based MRI Contrast Agent

Yifan Zhang1, Andre F Martins2, Dean A Sherry2, Christian E Anderson1, and Chris A Flask1

1Radiology, Case Western Reserve University, Cleveland, OH, United States, 2Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, United States

In this initial in vitro study, we used Magnetic Resonance Fingerprinting (MRF)-based T1 and T2 relaxation time maps to estimate the linear relationship between pH and relaxivity (r1 and r2) for a previously-described dysprosium (Dy) MRI contrast agent. These relaxivity estimates were then used to calculate MRF-based estimates of pH for each solution for comparison with gold-standard measurements by pH electrode at 7.0T (R = 0.93, p = <1e-6) and 9.4T (R = 0.68, p = 0.004). Results show MRF can be used in combination with a pH-sensitive paramagnetic MRI contrast agent to accurately estimate pH independent of agent concentration.

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