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Abstract #4561

Combining Parallel Imaging and Model-based Reconstruction for Isotropic 3D T2 mapping with Multi-Echo GRASE

Gian Franco Piredda1,2,3, Tom Hilbert1,2,3, Reto Meuli2, Josef Pfeuffer4, Jean-Philippe Thiran2,3, and Tobias Kober1,2,3

1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Application Development, Siemens Healthcare GmbH, Erlangen, Germany

Classical T2 mapping based on 2D multi-echo spin-echo sequences achieves only limited across-slice resolutions. For clinical use, acquisitions with high isotropic resolution are however desirable, resulting in clinically prohibitive scan times. To this end, we propose a 3D multi-echo gradient and spin echo sequence with CAIPIRINHA and an additional model-based acceleration for T2 estimation. The combination of these techniques allows for whole-brain T2 mapping with 1.6mm-isotropic resolution in 3:26 min. The proposed framework was tested both in phantom and in vivo experiments.

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