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Abstract #4589

Single Breath-Hold Diffusion MRI utilizing a Spiral TSE with Variable Flip Angle Refocusing

Naoharu Kobayashi1 and Michael Garwood1

1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States

A single breath-hold diffusion MRI sequence utilizing turbo spin echo (TSE) with variable flip angle refocusing and spiral readout is introduced. Flip angles of the refocus RF pulses were determined with the prospective extended phase graph method to minimize the impact of fluctuating refocusing echo signals in TSE. Spiral k-space sampling made the sequence tolerant to motion. The feasibility of the proposed sequence was tested in in vivo brain and thoracic imaging. The proposed single breath-hold diffusion sequence achieved diffusion-weighted imaging of the thoracic region without clear cardiac motion artifacts.

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