Though metal artifacts have been well-resolved in anatomical imaging by three dimensional multispectral imaging (3D-MSI) methods, diffusion weighted imaging (DWI) near metallic implants still remains a challenge, impeding various clinical applications. Point-Spread-Function encoded EPI (PSF-EPI) combined with Tilted-CAIPI can achieve highly accelerated distortion- and blurring-free high resolution DWI. By using an additional phase encoding, artifacts induced by severe susceptibility inhomogeneity around metal can be reduced even under a high acceleration rate. The reliable performance of PSF-EPI technique in metal artifacts reduction in DWI is demonstrated on phantom, in vitro swine forearm and in vivo patients.
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