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Abstract #4625

RF pulse design via time optimal control for combined excitation, refocusing and inversion

Christoph Stefan Aigner1, Armin Rund2, Christina Graf1, Karl Kunisch2, and Rudolf Stollberger1

1Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 2Institute for Mathematics and Scientific Computing, University of Graz, Graz, Austria

This work demonstrates a constrained joint design of minimum duration RF pulse and slice selective gradient waveforms for combined SMS excitation, refocusing and inversion scenarios. A hybrid trust-region semismooth Newton/quasi-Newton method with exact derivatives via adjoint calculus is used to solve the time optimal problem on fine spatial and temporal grids. Specific hardware and safety constraints, including maximal RF, slice selective gradient, slew rate amplitudes as well as global SAR estimates, guarantee practical applicability. High-resolution GRE, crushed SE and inversion recovery GRE slice profile measurements on a 3T MR system validate the numerical results.

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