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Abstract #4637

Improving pseudo-continuous arterial spin labelling at ultra-high field using a VERSE-guided parallel transmission strategy

Yan Tong1, Peter Jezzard1, Thomas W Okell1, and William T Clarke1

1Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Implementing ASL at ultra-high field is challenging due to increased specific absorption rate (SAR), along with B1+ and B0 inhomogeneity. Parallel transmission (pTx) provides additional degrees of freedom to mitigate B1+ inhomogeneity. Among various pTx strategies, RF shimming is a simple formulation that modulates the complex weights of each RF channel. In this study, we explored the possibility of using VERSE to further improve PCASL at 7T, and VERSE-guided RF shimming was shown to achieve improved SNR in perfusion-weighted images over power-matched Circularly-Polarised (CP) mode and RF-shimmed Gaussian labelling schemes.

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