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Abstract #4685

Fixed-Point MR Imaging for Early Gliobrastoma Detection

Zhao Li1, Chao-Hsiung Hsu2, Huiyuan Zheng2, and Yung-Ya Lin2

1Chemistry and Biochemistry, UCLA, Los Angeles, CA, United States, 2UCLA, Los Angeles, CA, United States

Problem Early detection of high-grade malignancy, such as GBM, remains challenging using MRI.

Methods A new approach using continuous-wave and feedback field to reach “fixed-point spin dynamics” was developed to enhances the local magnetic-field gradient variations due to irregular water contents and deoxyhemoglobin concentration in early GBM.

Results In vivo MR images and mappings acquired on orthotopic GBM mice using “fixed-point pulse sequence” shows 3-4 times of enhancement in GBM contrast than the best conventional images acquired.

Conclusion Simulations and in vivo GBM mouse models validated the superior contrast/sensitivity and robustness of fixed-point spin dynamics method towards early GBM detection.

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