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Abstract #4693

Effects of Image Sharpening on the Accuracy of quantitative-MRI (qMRI) Maps.

Ryan McNaughton1, Mina Botros1, Xin Zhang1, and Hernan Jara1

1Boston University, Boston, MA, United States

Purpose: To study the effects of image sharpening and low spatial frequency removal on the quality of qMRI maps of T1, T2, and proton density (PD). Methods: Previously developed qMRI algorithms, augmented with specialized image filters, were tested with a gel based phantom containing three distinct solutions of variable gadolinium, sucrose, and agarose concentrations. Results: Images were successfully sharpened without significantly effecting pixel values of T1 and T2 weighted maps, while removing PD map spatial artifacts in the gadolinium vials. Conclusion: Unsharp masking and spatial flattening algorithms are effective methods for enhancing qMRI quality toward generating more accurate Synthetic-MRI maps.

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