We propose an imaging sequence for Simultaneous MultiSlice Multi-Shot EPI (SMS-MS EPI) with wave-CAIPI controlled aliasing, to significantly reduce the imaging time and geometric distortion in gradient echo imaging. We extend the MUSSELS low-rank constrained parallel imaging technique to SMS acceleration and exploit the similarities among the EPI shots for improved reconstruction. In simulations, we demonstrate the capability of our sequence to incorporate wave-CAIPI encoding, which allows higher acceleration rates by fully harnessing the three-dimensional encoding capability of multi-channel receive arrays. Using MUSSELS with wave-SMS, whole-brain T2*-weighted images at 1 mm isotropic resolution can be obtained at the total acceleration of Rtotal=24 (RinplanexRSMS=8x3), corresponding to an acquisition with high image quality and geometric fidelity.
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