Investigations of brain structure in schizophrenia using magnetic resonance imaging (MRI) have identified variations in regional grey matter (GM) volume throughout the brain but the results are mixed. This study aims to investigate whether the inconsistent voxel-based morphometry (VBM) findings in schizophrenia are due to the use of different software packages. our data indicate that the GM volume differences between FESZ and HCs depend on which software are used(FSL, SPM), algorithms of GM tissue segmentation and image registration might contribute to these disparate results.
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