We proposed a new synthetic-MRI technique combined with water suppression to reduce CSF partial volume effects (PVE) artifacts problematic in a conventional synthetic-MRI. Our water suppression was simply achieved by subtracting additionally acquired long-TE SE image of water signal dominant. After the quantitative parameter maps of original and with water suppression were generated, water-suppressed synthetic-SE and -FLAIR images were calculated using those suitable combinations. We demonstrated that CSF PVE artifacts were dramatically reduced in our proposed synthetic-FLAIR, and furthermore that, by the two-compartment model simulation and volunteer MR brain study, our synthetic-SE provided better gray-white matter contrasts compared to our synthetic-FLAIR.
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