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Abstract #4927

Quantitative Susceptibility Mapping (QSM) MRI in a Collagenase Rat Model of Intracerebral Hemorrhage (ICH)

*Kimmo Lehtimäki1, Artem Shatillo1, Elina Latonummi1, and Antti Nurmi1

1Charles River Discovery, Kuopio, Finland

Management of ICH is critical for the recovery and appropriate imaging methods to follow the process are needed. ICH was induced by intra-striatal infusion of collagenase IV. Study consisted T2/diffusion-maps at 6 hours, 1, 3 and 14 days and ex vivo QSM at D1 and D3. QSM revealed large ICH lesions with low susceptibility core and high susceptibility outer rim. Histogram comparison showed modulation in susceptibilities; D1 with higher proportion edema processes and iron than D3. QSM method seems particularly suitable for in vivo applications to study ICH in rats due to proper lesion size and clear presence of iron.

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