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Abstract #4987

Manganese-based macrocyclic chelates as a potential novel MRI contrast agent – relaxometry & imaging

Wibeke Nordhøy1, Robin Anthony Birkeland Bugge1, Tuva Hope1, Deirdre B Cassidy2, Brian Bales3, and Atle Bjørnerud1,4

1Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway, 2GE Healthcare Life Sciences, Chalfont St Giles, United Kingdom, 3GE Global Research, Niskayuna, NY, United States, 4Department of Physics, Oslo University, Oslo, Norway

In this study, novel Manganese-based contrast agents (MnCAs) were evaluated by relaxometry techniques (NMR and phantom imaging) and tested in naïve pigs using a contrast-enhanced MRA protocol and compared to the well-established agent GdDOTA. Despite some differences in T1 and T2 relaxation performance, both MnCAs and GdDOTA provided strong vascular T1-enhancement in naïve pig imaging thus providing initial evidence that MnCAs could be utilized for a clinical application.

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