Abstract #4987

Manganese-based macrocyclic chelates as a potential novel MRI contrast agent – relaxometry & imaging

Wibeke Nordhøy¹, Robin Anthony Birkeland Bugge¹, Tuva Hope¹, Deirdre B Cassidy², Brian Bales³, and Atle Bjørnerud^1,4

¹Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway, ²GE Healthcare Life Sciences, Chalfont St Giles, United Kingdom, ³GE Global Research, Niskayuna, NY, United States, ⁴Department of Physics, Oslo University, Oslo, Norway

In this study, novel Manganese-based contrast agents (MnCAs) were evaluated by relaxometry techniques (NMR and phantom imaging) and tested in naïve pigs using a contrast-enhanced MRA protocol and compared to the well-established agent GdDOTA. Despite some differences in T1 and T2 relaxation performance, both MnCAs and GdDOTA provided strong vascular T1-enhancement in naïve pig imaging thus providing initial evidence that MnCAs could be utilized for a clinical application.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.