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Abstract #4996

Artifacts in dynamic CEST MRI due to motion and field shifts – implications for glucoCEST MRI at 3T

Moritz Zaiss1, Kai Herz1, Anagha Deshmane1, Mina Kim2, Xavier Golay2, Tobias Lindig3, Benjamin Bender3, Ulrike Ernemann3, and Klaus Scheffler1

1High-field magnetic resonance center, Max Planck Institute for biological cybernetics, Tübingen, Germany, 2University College London, London, United Kingdom, 3Diagnostic & Interventional Neuroradiology, University Clinic Tuebingen, Tübingen, Germany

Dynamic glucose enhanced imaging yields expected CEST effects that are rather small in tissue especially at clinical field strengths (<2 %). Small movements during the dynamic CEST measurement together with a subtraction-based evaluation can lead to pseudo CEST effects of the same order of magnitude. We studied these effects by virtual difference images of a basline scan that were altered by the rigid body transformations and B0 shifts. Minor motion (0.6 mm translations) and B0 artifacts (7 Hz shift) can lead to pseudo effects in the order of 1% in dynamic CEST imaging, despite no glucose was injected at all.

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