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Abstract #5029

Reproducibility of Selective Localised T2-Relaxation-Under-Spin-Tagging (SL-TRUST) for Regional Cerebral Oxygen Extraction Fraction

Caitlin Fern O'Brien1, Thomas Okell1, and Peter Jezzard1

1Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom

In this study, we offer preliminary results of a reproducibility study on a novel sequence: Selective Localised TRUST (SL-TRUST). SL-TRUST is an MR acquisition method for acquiring spatially specific cerebral tissue oxygen extraction fraction (OEF) values through measurements of venous blood T2 in the superior sagittal sinus. Three subjects underwent four scan sessions over a seven day period and the inter/intra session variability of SL-TRUST was evaluated. The resulting venous blood T2 and tissue OEF values from spatially specific regions (a single hemisphere, and a 70x80x80mm tissue region) are compared to whole brain measures obtained using TRUST.

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