Abstract #5059

Optimal temporal resolution for accurate AIF measurement and error-constrained pharmacokinetic modelling of DCE data

Silvin P. Knight¹, James F. Meaney¹, and Andrew J. Fagan^1,2

¹National Centre for Advanced Medical Imaging (CAMI), St James Hospital / School of Medicine, Trinity College University of Dublin, Dublin 8, Ireland, ²Department of Radiology, Mayo Clinic, Rochester, MN, USA, Rochester, MN, United States

A highly-controlled and validated phantom-based method was used to investigate the effects of acquisition temporal resolution (T_res) on the arterial input function (AIF) measurement accuracy and precision for DCE-MRI. The propagation of these AIF measurement errors into errors in pharmacokinetic modelling parameter values could thus also be investigated. Guideline T_res values which can be used to constrain errors in K^trans, k_ep and v_e within defined limits (e.g. <5%, <10% etc) are presented.

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