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Abstract #5059

Optimal temporal resolution for accurate AIF measurement and error-constrained pharmacokinetic modelling of DCE data

Silvin P. Knight1, James F. Meaney1, and Andrew J. Fagan1,2

1National Centre for Advanced Medical Imaging (CAMI), St James Hospital / School of Medicine, Trinity College University of Dublin, Dublin 8, Ireland, 2Department of Radiology, Mayo Clinic, Rochester, MN, USA, Rochester, MN, United States

A highly-controlled and validated phantom-based method was used to investigate the effects of acquisition temporal resolution (Tres) on the arterial input function (AIF) measurement accuracy and precision for DCE-MRI. The propagation of these AIF measurement errors into errors in pharmacokinetic modelling parameter values could thus also be investigated. Guideline Tres values which can be used to constrain errors in Ktrans, kep and ve within defined limits (e.g. <5%, <10% etc) are presented.

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