Abstract #5065

3D-Printed whole-brain holder for multiple orientation magnetic susceptibility measurements and precise dissection

Kwok-Shing Chan¹, Jeroen Mollink^2,3, Renaud Hedouin¹, Norbert Hermesdorf⁴, Anne-Marie van Cappellen van Walsum², and José P. Marques¹

¹Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, ²Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands, ³Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, Oxford, United Kingdom, ⁴Faculty of Social Sciences, Radboud University, Nijmegen, Netherlands

In this study, we present a whole-brain holder for ex vivo experiments which allows rotating the sample inside a conventional head coil (while ensuring no deformation occurs) and provides guidance for precise correspondence between the MR data and excised tissue. We demonstrate some of these features with two experiments aimed at validating magnetic susceptibility measurements using MRI, where small 5mm cube samples located in different slices through the whole brain can be excised with great precision.

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