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Abstract #5065

3D-Printed whole-brain holder for multiple orientation magnetic susceptibility measurements and precise dissection

Kwok-Shing Chan1, Jeroen Mollink2,3, Renaud Hedouin1, Norbert Hermesdorf4, Anne-Marie van Cappellen van Walsum2, and José P. Marques1

1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, 2Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands, 3Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, Oxford, United Kingdom, 4Faculty of Social Sciences, Radboud University, Nijmegen, Netherlands

In this study, we present a whole-brain holder for ex vivo experiments which allows rotating the sample inside a conventional head coil (while ensuring no deformation occurs) and provides guidance for precise correspondence between the MR data and excised tissue. We demonstrate some of these features with two experiments aimed at validating magnetic susceptibility measurements using MRI, where small 5mm cube samples located in different slices through the whole brain can be excised with great precision.

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