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Abstract #0070

Digestive disorders in Cystic Fibrosis: Transit, Motility and MRI Signs of Small Intestinal Bacterial Overgrowth

Neele S Dellschaft1,2, Christabella Ng3, Caroline Hoad1,2, Luca Marciani2,4, Robin Spiller2,4, Penny Gowland1,2, Alan Smyth2,3, and Giles Major2,4
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, 3Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Nottingham, United Kingdom, 4Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom

Cystic Fibrosis (CF) is a genetic disease leading to sticky mucus. We used MRI to characterise the effect of CF on gastrointestinal function, comparing people with CF to matched healthy controls. People with CF had slower orocaecal transit times. No change in gastric emptying rate was apparent but more free water was present in their small bowel with reduced small bowel motility and a reduced gastro-ileal reflex. Some images suggested increased bacterial load in the small bowel. CF colons were larger. These findings are consistent with sticky chyme impeding ileal emptying into the colon, causing obstruction to flow, and constipation.

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