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Abstract #0078

Evaluation of brain MRI quality in natural sleep vs anaesthesia in infants within 6 months of life.

Paolo Bosco1, Simona Fiori2, Rosa Pasquariello1, Elena Scaffei2,3, Michela Tosetti1, and Laura Biagi1
1Laboratory of Medical Physics and Magnetic Resonance, IRCCS Stella Maris Foundation, Pisa, Italy, 2Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy, 3Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Natural sleep brain MRI (nsMRI) up to 6 months of life to support early diagnosis in term and preterm infants at high risk for cerebral palsy and other developmental disorders is still far from clinical practice, due to unproven feasibility and quality. We extracted some measures of quality (signal to noise ratio, contrast to noise ratio in a cohort of 23 and 53 infants who underwent sedation or natural sleep brain MR respectively. Most of the quality measures extracted across different MR modalities did not differ between nsMRI and sedation MRI (sMRI) suggesting the feasibility of nsMRI at younger ages.

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