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Abstract #0083

In vivo evaluation of white matter abnormalities in children with DMD using diffusion MRI

Jitender Saini1, Veeramani Preethish Kumar2, Apurva Shah3, Manoj Kumar4, Madhura Ingalhalikar5, and Nalini Atchayaram 2
1Nueroimaging and Interventional Radiology, National Institute of Mental Health and, Bangalore, India, 2Neurology, National Institute of Mental Health and, Bangalore, India, 33Symbiosis Centre for Medical Image Analysis, Symbiosis International University, Pune, India, 4Neuroimaging and Interventional Radiology, National Institute of Mental Health and, Bangalore, India, 5Symbiosis Centre for Medical Image Analysis, Symbiosis International University, Pune, India

Duchenne muscular dystrophy (DMD), a genetically inherited X-linked neuromuscular disorder characterised by progressive muscle weakness and significant non-motor manifestations like poor IQ, and neuropsychiatric illnesses. In this study, we evaluate white matter (WM) abnormalities in DMD patients using diffusion tensor imaging (DTI). We observed widespread WM changes in DMD patients and the presence of distal mutation was associated with poor clinical and neuropsychological profile with severe and spatially more WM abnormalities.

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