Abstract #0100

Characterising thalamic and anterior cingulate GABA, Glx and GSH in the neonatal brain with HERMES

Maria Yanez Lopez¹, Anthony N Price¹, Emer Hughes¹, Nicolaas AJ Puts^2,3, Richard AE Edden^2,3, Grainne McAlonan⁴, Tomoki Arichi^1,5, and Enrico De Vita⁶

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, ⁵Department of Bioengineering, South Kensington Campus, Imperial College London, London, United Kingdom, ⁶Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

We measured GABA, Glx and GSH levels in a population of healthy neonates, using HERMES at 3T. We show that HERMES can be used to measure significant regional differences (in this case between the thalamus and anterior cingulate cortex). Further application of this method to study how these levels and balance are altered by early-life brain injury or genetic risk can provide important new knowledge about the pathophysiology underlying neurodevelopmental disorders.

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