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Abstract #0100

Characterising thalamic and anterior cingulate GABA, Glx and GSH in the neonatal brain with HERMES

Maria Yanez Lopez1, Anthony N Price1, Emer Hughes1, Nicolaas AJ Puts2,3, Richard AE Edden2,3, Grainne McAlonan4, Tomoki Arichi1,5, and Enrico De Vita6
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, 5Department of Bioengineering, South Kensington Campus, Imperial College London, London, United Kingdom, 6Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

We measured GABA, Glx and GSH levels in a population of healthy neonates, using HERMES at 3T. We show that HERMES can be used to measure significant regional differences (in this case between the thalamus and anterior cingulate cortex). Further application of this method to study how these levels and balance are altered by early-life brain injury or genetic risk can provide important new knowledge about the pathophysiology underlying neurodevelopmental disorders.

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