Abstract #0111

Feasibility of using transcranial magnetic stimulation devices to study magnetically induced cardiac stimulation in pigs

Valerie Klein^1,2, Mathias Davids^1,2,3, Christopher Nguyen^2,3,4, Lothar R. Schad¹, Lawrence L. Wald^2,3,5, and Bastien Guérin^2,3

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²A. A. Martinos Center for Biomedical Imaging, Department of Radiologoy, Massachusetts General Hospital, Charlestown, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

This work evaluates the potential of porcine cardiac stimulation (CS) studies using transcranial magnetic stimulation (TMS) devices with the aim of determining appropriate safety limits for MRI gradients. We investigated the electric fields induced in electromagnetic porcine models and found that typical TMS coils may not generate fields strong enough for CS. Larger coplanar coils, however, may be suitable for CS studies. In addition to these investigations, we created a porcine model from MRI Dixon and cardiac CINE measurements. The use of such custom models of the animal under experimentation will facilitate the comparison between measured and simulated CS thresholds.

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