Abstract #0117

A Pilot Clinical Study of Quantitative Silicone Oxygen Sensors in Cervical Cancer

Gregory James Ekchian¹, Junichi Tokuda², Jahanara Freedman¹, Hannah Harens¹, Robert Cormack³, Larissa Lee³, and Michael Cima^1,4

¹Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States, ²Radiology, Brigham and Women's Hospital, Boston, MA, United States, ³Radiation Oncology, Brigham and Women's Hospital, Boston, MA, United States, ⁴Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States

We report on the first-in-human evaluation of a class of silicone oxygen sensors capable of both high sensitivity and repeated and long-term monitoring of tumor oxygen levels. We are evaluating the use of this sensor in patients receiving high dose rate brachytherapy for cervical cancer. This sensor is a direct and quantitative measurement of tumor oxygen. Low oxygen regions of tumors are more resistant to many common forms of treatment. Understanding tumor oxygen levels can enable personalized radiation and chemotherapy treatments to overcome resistance and improve outcomes for patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.