In this work, we applied BOLD fMRI in Rhesus monkey on a 3T MR system and investigated the functional effects induced by transcranial ultrasound stimulation (TUS) in both the target spot (the primary visual cortex) and the remote interconnected brain regions. We found that TUS can evoke BOLD reaction not only on the region-specific region but also the interconnected areas in the monkey brain. Additionally, our results demonstrated that the temporal features of BOLD time courses of TUS on the primary visual cortex and those of real visual stimulation have no significant difference in the regions of primary visual pathway.
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