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Abstract #0127

Detecting glycolytic metabolism in glioblastoma using a new 1H MRS and [6,6'-2H2]glucose infusion based approach

Laurie J Rich1, Puneet Bagga1, Gabor Mizsei1, Mitchell D Schnall1, John A Detre2, Mohammad Haris3, and Ravinder Reddy1
1Radiology, University of Pennyslvania, Philadelphia, PA, United States, 2Neurology, University of Pennyslvania, Philadelphia, PA, United States, 3Research Branch, Qatar University, Doha, Qatar

A key hallmark of malignant tissues is a metabolic shift from oxidative phosphorylation to glycolytic metabolism, leading to increased lactate production. Probing the kinetics of lactate production in vivo may play a key role in studying disease mechanisms and developing biomarkers of treatment response. Here, we developed a new approach for studying glycolytic metabolism in glioblastoma by combining 1H MRS with infusion of deuterated glucose. Infusion of [6,6'-2H2]glucose leads to downstream deuterium labeling of lactate, resulting in a reduction in the 1.33 ppm lactate peak on 1H MRS and making it is possible to monitor the metabolic turnover of lactate.

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