Abstract #0130

Hyperpolarized 13C-glucose MRS: a potential biosensor to visualize the infiltrative front in GBM

Mor Mishkovsky¹, Olga Gusyatiner², Bernard Lanz¹, Cristina Cudalbu³, Irene Vassallo², Marie-France Hamou², Jocelyne Bloch², Arnaud Comment⁴, Rolf Gruetter^1,3,5,6, and Monika Hegi²

¹Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ³Centre d'Imagerie Biomédicale (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴General Electric Healthcare, Chalfont St Giles, United Kingdom, ⁵Department of Radiology, University of Geneva (UNIGE), Geneva, Switzerland, ⁶Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland

Glioblastoma (GBM) is the most malignant primary brain tumor in adults. Aberrant glucose metabolism is considered a hallmark of cancer, via the so-called ‘Warburg Effect’, however recent studies show distinct metabolic profile associated with the invasive phenotype in GBM, indicating active glucose oxidation. Hyperpolarized (HP) endogenous compounds, provides real-time metabolic information which is related to enzymatic activity. The aim of the present study was to apply HP ¹³C-glucose MRS in patient-derived GBM models and to investigate glucose metabolism in the infiltrative front of GBM, which potentially would enable to differentiate the invasive front of GBM from normal brain.

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