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Abstract #0166

Evolution of tumour mechanical properties under static preload as potential biomarker of solid stress

Gwenaël Pagé1, Laurent Besret2, Marion Tardieu1, Maïlys Vidal1, Bernard Van Beers1,3, and Philippe Garteiser1
1Laboratory of Biomarkers in Imaging, Center of Research on Inflammation, UMR 1149 Inserm-Université de Paris, Paris, France, 2Sanofi R&D, Vitry-sur-Seine, France, 3Department of Radiology, Beaujon University Hospital Paris Nord, Clichy, France

The purpose of this study was to assess in two different human liver tumours the correlation between tumour solid stress and changes of mechanical properties under preload. MR elastography acquisitions were performed at different pressure levels by externally compressing the tumour with an inflatable balloon. Reference values for tumour fluid pressure and solid stress were acquired with a catheterized pressure transducer. The results, obtained in two liver tumour types with largely different basal mechanical properties, show that the evolution of tumour elasticity under preload is correlated with the tumour solid stress and could be a potential biomarker of tumour pressure.

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