In MR elastography, the propagation of three-dimensional wave motion is acquired to assess mechanical tissue properties. We here propose an accelerated approach of the multiphase DENSE-MRE acquisition scheme which additionally includes three-dimensional motion encoding besides the multiple phase offsets within one TR. In addition to phantom experiments, this multi-axes encoding concept was also investigated in the human brain in vivo. The gathered wave images and shear modulus maps are confirmed by three consecutive single-axes multiphase DENSE-MRE acquisitions for x-, y- and z-motion encoding direction. With this concept, the acquisition can be accelerated up to a factor of 3.
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