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Abstract #0184

Microscopic multifrequency MR elastography with 40 micrometer spatial resolution: Application to murine neural tissue specimens

Gergely Bertalan1, Bettina Müller2, Leif Schröder3, Heiko Tzschätzsch1, Mehrgan Shahryari1, Helge Herthum1, Jing Guo1, Jürgen Braun4, and Ingolf Sack1
1Department of Radiology, Charite Universitätsmedizin Berlin, Berlin, Germany, 2Tierhaltung CCM, Charite Universitätsmedizin Berlin, Berlin, Germany, 3Molecular Imaging, Leibniz Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany, 4Department of medical Informatics, Charite Universitätsmedizin Berlin, Berlin, Germany

The purpose of this study was the development of multifrequency MR elastography (MRE) of tissue samples with 40 micrometer pixel edge size for analyzing the mechanical properties of murine neural tissue. The new technique revealed in specimens of cerebellum and cortical brain areas that white matter is significantly stiffer than gray matter. Microscopic multifrequency MRE provides insight into micro mechanical structures of ex-vivo soft tissues and might be used in the future to investigate fresh biopsy samples.

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