Abstract #0184

Microscopic multifrequency MR elastography with 40 micrometer spatial resolution: Application to murine neural tissue specimens

Gergely Bertalan¹, Bettina Müller², Leif Schröder³, Heiko Tzschätzsch¹, Mehrgan Shahryari¹, Helge Herthum¹, Jing Guo¹, Jürgen Braun⁴, and Ingolf Sack¹

¹Department of Radiology, Charite Universitätsmedizin Berlin, Berlin, Germany, ²Tierhaltung CCM, Charite Universitätsmedizin Berlin, Berlin, Germany, ³Molecular Imaging, Leibniz Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany, ⁴Department of medical Informatics, Charite Universitätsmedizin Berlin, Berlin, Germany

The purpose of this study was the development of multifrequency MR elastography (MRE) of tissue samples with 40 micrometer pixel edge size for analyzing the mechanical properties of murine neural tissue. The new technique revealed in specimens of cerebellum and cortical brain areas that white matter is significantly stiffer than gray matter. Microscopic multifrequency MRE provides insight into micro mechanical structures of ex-vivo soft tissues and might be used in the future to investigate fresh biopsy samples.

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