One of the major challenges in constructing a longitudinal structural template of the older adult brain is to ensure spatio-temporal consistency. In this work, a new method was introduced to construct a spatio-temporally consistent longitudinal structural template of the older adult brain based on high quality cross-sectional older adult data from a large cohort. The new template was compared to templates generated with previously published methods in terms of spatio-temporal consistency, image quality, and representativeness of age-related brain changes, and was shown to have superior performance.
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