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Abstract #0198

Development of a spatio-temporally consistent longitudinal structural template of the older adult brain

Abdur Raquib Ridwan1, Mohammad Rakeen Niaz1, Yingjuan Wu1, Xiaoxiao Qi1, David A. Bennett2, and Konstantinos Arfanakis1,2
1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease center, Rush University Medical Center, Chicago, IL, United States

One of the major challenges in constructing a longitudinal structural template of the older adult brain is to ensure spatio-temporal consistency. In this work, a new method was introduced to construct a spatio-temporally consistent longitudinal structural template of the older adult brain based on high quality cross-sectional older adult data from a large cohort. The new template was compared to templates generated with previously published methods in terms of spatio-temporal consistency, image quality, and representativeness of age-related brain changes, and was shown to have superior performance.

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