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Abstract #0201

Introducing Substantia Nigra Iron Content and Neuromelanin Overlap to Distinguish Parkinson’s Patients from Healthy Controls

Naying He1, Kiarash Ghassaban2,3, Pei Huang4, Zenghui Cheng1, Yan Li1, Mojtaba Jokar5, Sean K. Sethi2,5, Weibo Chen6, Shengdi Chen4, Fuhua Yan1, and Ewart Mark Haacke1,2,5
1Radiology, Ruijin Hospital, Shanghai Jiaotong Univ. School of Medicine, Shanghai, China, Shanghai, China, 2Department of Radiology, Wayne State University, Detroit, MI, United States, 3Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, 4Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 5Magnetic Resonance Innovations, Inc., Bingham Farms, Bingham Farms, MI, United States, 6Philips Healthcare, Shanghai, China

A total of 40 Parkinson’s disease (PD) patients and 40 age- and sex-matched healthy controls (HC) were scanned using a single 3D gradient echo magnetization transfer sequence to measure neuromelanin and iron content, and the overlap between them. These measures showed reliable results indicative of powerful diagnostic biomarkers to differentiate PD patients from HCs. An increase in iron content was seen in the substantia nigra for the PD patients while the neuromelanin volume decreased. The best predictor, however, was found to be the combination of neuromelanin volume and its overlap with iron-containing substantia nigra which yielded an AUC of 98%.

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