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Abstract #0203

Investigating Spatiotemporal Changes in the Substantia Nigra of Patients with Prodromal and Clinical Parkinson's Disease

Emma Biondetti1,2,3, Rahul Gaurav1,2,3, Lydia Yahia-Cherif1,3, Graziella Mangone4, Nadya Pyatigorskaya1,2,3,5, Romain Valabrègue1,3, Claire Ewenczyk2,3, Matthew Hutchison6, Jean-Christophe Corvol3,4,7, Marie Vidailhet2,3,7, and Stéphane Lehéricy1,2,3,5
1Brain and Spine Institute - ICM, Centre for NeuroImaging Research - CENIR, Paris, France, 2Brain and Spine Institute - ICM, Team "Movement Investigations and Therapeutics", Paris, France, 3Brain and Spine Institute - ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France, 4National Institute of Health and Medical Research - INSERM, Clinical Investigation Centre, Pitié-Salpêtrière Hospital, Paris, France, 5Department of Neuroradiology, Pitié-Salpêtrière Hospital, Public Assistance - Paris Hospitals (AP-HP), Paris, France, 6Biogen Inc., Cambridge, MA, United States, 7Department of Neurology, Pitié-Salpêtrière Hospital, Public Assistance - Paris Hospitals (AP-HP), Paris, France

Parkinson's disease (PD) and idiopathic rapid eye movement sleep behaviour disorder (iRBD, a prodromal condition of Parkinsonism) are characterised by the progressive loss of neuromelanin-containing neurons in the substantia nigra (SN). Based on longitudinal neuromelanin-sensitive magnetic resonance imaging (NM-MRI) of healthy controls, patients with iRBD and patients with PD, and voxel-wise analysis of NM-MRI on a study-specific anatomical brain template, we showed the temporal evolution of SN atrophy in disease. We also found significant correlations between temporal changes in the NM-MRI signal-to-noise ratio and clinical scores of disease severity, reflecting the functional organisation (motor, cognition and behaviour/mood) of the SN.

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