Abstract #0203

Investigating Spatiotemporal Changes in the Substantia Nigra of Patients with Prodromal and Clinical Parkinson's Disease

Emma Biondetti^1,2,3, Rahul Gaurav^1,2,3, Lydia Yahia-Cherif^1,3, Graziella Mangone⁴, Nadya Pyatigorskaya^1,2,3,5, Romain Valabrègue^1,3, Claire Ewenczyk^2,3, Matthew Hutchison⁶, Jean-Christophe Corvol^3,4,7, Marie Vidailhet^2,3,7, and Stéphane Lehéricy^1,2,3,5

¹Brain and Spine Institute - ICM, Centre for NeuroImaging Research - CENIR, Paris, France, ²Brain and Spine Institute - ICM, Team "Movement Investigations and Therapeutics", Paris, France, ³Brain and Spine Institute - ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France, ⁴National Institute of Health and Medical Research - INSERM, Clinical Investigation Centre, Pitié-Salpêtrière Hospital, Paris, France, ⁵Department of Neuroradiology, Pitié-Salpêtrière Hospital, Public Assistance - Paris Hospitals (AP-HP), Paris, France, ⁶Biogen Inc., Cambridge, MA, United States, ⁷Department of Neurology, Pitié-Salpêtrière Hospital, Public Assistance - Paris Hospitals (AP-HP), Paris, France

Parkinson's disease (PD) and idiopathic rapid eye movement sleep behaviour disorder (iRBD, a prodromal condition of Parkinsonism) are characterised by the progressive loss of neuromelanin-containing neurons in the substantia nigra (SN). Based on longitudinal neuromelanin-sensitive magnetic resonance imaging (NM-MRI) of healthy controls, patients with iRBD and patients with PD, and voxel-wise analysis of NM-MRI on a study-specific anatomical brain template, we showed the temporal evolution of SN atrophy in disease. We also found significant correlations between temporal changes in the NM-MRI signal-to-noise ratio and clinical scores of disease severity, reflecting the functional organisation (motor, cognition and behaviour/mood) of the SN.

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