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Abstract #0233

MRI profiling of focal cortical dysplasia using advanced diffusion models

Sara Lorio1, Sophie Adler2, Roxana Gunny3, Felice D'Arco3, Enrico Kaden2, Konrad Wagstyl2, Thomas Jacques2,3, Chris Clark2, Helen Cross2, Torsten Baldeweg2, and David W. Carmichael1
1King's College London, LONDON, United Kingdom, 2UCL, London, United Kingdom, 3Great Ormond Street Hospital, London, United Kingdom

Lesion detection and sub-typing for focal cortical dysplasia (FCD), a frequent cause of drug-resistant epilepsy, remain challenging on conventional MRI. New diffusion models such as the spherical mean techniques (SMT) and the neurite orientation dispersion and density imaging (NODDI) provide measurements that are potentially more specific to abnormal tissue microstructure. Quantitative analysis of lesion profiling demonstrated significant changes on NODDI and SMT maps proportional to neurites density, as well on microscopic mean, radial and axial diffusivities. Moreover, signal changes specific to FCD lesions sub-types were observed on those maps, suggesting they can provide features useful for automated lesion detection.

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