Abstract #0379

Simultaneous High-Resolution 3D MRSI and Oxygen Extraction Fraction Mapping in Acute Stroke Using SPICE

Tianxiao Zhang¹, Tianyao Wang², Zengping Lin¹, Rong Guo^3,4, Yudu Li^3,4, Yibo Zhao^3,4, Ziyu Meng^1,3, Jun Liu², Danhong Wu⁵, Zheng Jin⁶, Xin Yu⁷, Zhi-Pei Liang^3,4, and Yao Li¹

¹Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Neurology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ⁶Shanghai Minhang Hospital of Integrated Traditional Chinese and Western Medicine Hospital, Shanghai, China, ⁷Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Mapping the concurrent changes in oxygen extraction fraction (OEF) and neurometabolic markers could provide a powerful tool for evaluation of brain tissue viability after stroke. In this work, we investigated the feasibility of fast simultaneous 3D brain OEF and neurometabolic imaging noninvasively in acute ischemic stroke using SPICE. We achieved concurrent mapping of OEF (1.2×1.2×1.2 mm³ nominal resolution) and MRSI (2.0×3.0×3.0 mm³ nominal resolution) within a 7-minute scan. Our experimental results demonstrated the feasibility of mapping OEF and neurometabolic alterations in acute stroke.

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