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Abstract #0379

Simultaneous High-Resolution 3D MRSI and Oxygen Extraction Fraction Mapping in Acute Stroke Using SPICE

Tianxiao Zhang1, Tianyao Wang2, Zengping Lin1, Rong Guo3,4, Yudu Li3,4, Yibo Zhao3,4, Ziyu Meng1,3, Jun Liu2, Danhong Wu5, Zheng Jin6, Xin Yu7, Zhi-Pei Liang3,4, and Yao Li1
1Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Neurology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 6Shanghai Minhang Hospital of Integrated Traditional Chinese and Western Medicine Hospital, Shanghai, China, 7Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Mapping the concurrent changes in oxygen extraction fraction (OEF) and neurometabolic markers could provide a powerful tool for evaluation of brain tissue viability after stroke. In this work, we investigated the feasibility of fast simultaneous 3D brain OEF and neurometabolic imaging noninvasively in acute ischemic stroke using SPICE. We achieved concurrent mapping of OEF (1.2×1.2×1.2 mm3 nominal resolution) and MRSI (2.0×3.0×3.0 mm3 nominal resolution) within a 7-minute scan. Our experimental results demonstrated the feasibility of mapping OEF and neurometabolic alterations in acute stroke.

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