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Abstract #0387

Deuterium (2H) magnetic resonance spectroscopy for monitoring chemotherapeutic response in vitro

Josephine L Tan1,2, Daniel Djayakarsana1,2, Rachel W Chan2, Colleen Bailey1,2, and Angus Z Lau1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

Deuterium (2H) magnetic resonance spectroscopy (MRS) is a novel metabolic imaging method that can measure aberrant glucose metabolism in cancer. In this abstract, we use 2H MRS to measure metabolic changes in acute myeloid leukemia (AML) cells after treatment with cisplatin. We show that this method is sensitive to differences in lactate levels, produced via glycolysis of deuterium-enriched glucose at 7T. These studies demonstrate the potential of 2H MRS to monitor chemotherapeutic response.

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