Abstract #0387

Deuterium (2H) magnetic resonance spectroscopy for monitoring chemotherapeutic response in vitro

Josephine L Tan^1,2, Daniel Djayakarsana^1,2, Rachel W Chan², Colleen Bailey^1,2, and Angus Z Lau^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

Deuterium (²H) magnetic resonance spectroscopy (MRS) is a novel metabolic imaging method that can measure aberrant glucose metabolism in cancer. In this abstract, we use ²H MRS to measure metabolic changes in acute myeloid leukemia (AML) cells after treatment with cisplatin. We show that this method is sensitive to differences in lactate levels, produced via glycolysis of deuterium-enriched glucose at 7T. These studies demonstrate the potential of ²H MRS to monitor chemotherapeutic response.

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