Abstract #0392

Sodium Relaxometry using Magnetic Resonance Fingerprinting

Fabian J. Kratzer^1,2, Sebastian Schmitter^1,3, Armin M. Nagel^1,4,5, Nicolas G. R. Behl⁶, Benjamin R. Knowles¹, Peter Bachert^1,2, Mark E. Ladd^1,2,7, and Sebastian Flassbeck¹

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, Ruprecht-Karls University Heidelberg, Heidelberg, Germany, ³Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, ⁴Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁵Institute of Medical Physics, Friedrich-Alexander-Universität (FAU), Erlangen, Germany, ⁶Siemens Healthcare GmbH, Erlangen, Germany, ⁷Faculty of Medicine, Ruprecht-Karls University Heidelberg, Heidelberg, Germany

Sodium relaxation times have been shown to be altered in several diseases. However, due to short relaxation times and low in-vivo signal, measurement times in sodium relaxometry on the order of 1h were reported for both, longitudinal and transversal relaxation constants. In this work, a novel sodium relaxometry method based on Magnetic Resonance Fingerprinting (MRF) principles is presented, which enables simultaneous quantification of T₁, T_2s^*, T_2l^*, T₂^* and ΔB₀, with automatic distinction between bi- and monoexponential transverse relaxation.

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