The systemic oscillation of the blood flow in cerebrum and cerebellum may vary with gliomas of different malignancy, resulting in neurovascular uncoupling and abnormal perfusion. In this study, we investigated the implication of glioma on the oscillation of cerebral blood flow based on time-shifted rs-fMRI. HGGs induces more widely alterations in the spontaneous fluctuations of cerebral and cerebellar blood flow at the global scale. Vascular oscillation changes derived from rs-fMRI may provide a novel insight for the assessment of the functional plasticity and its clinical relevance in the interpretation of the psychological and psychiatric symptoms in subjects with glioma.
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