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Abstract #0428

Feasibility of Structural and Phase-Resolved Functional Lung (PREFUL) MRI in Free-Breathing Neonates

Brandon Zanette1, Samal Munidasa1,2, Marcus J Couch1, Elaine Stirrat1, Eric Schrauben1, Robert Grimm3, Andreas Voskrebenzev4,5, Jens Vogel-Claussen4,5, Ravi Seethamraju6, Christopher K Macgowan1,2, Mary-Louise C Greer7,8, Emily Tam9,10, and Giles Santyr1,2
1Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3MR Predevelopment, Siemens Healthcare, Erlangen, Germany, 4Diagnostic and Intervetional Radiology, Hannover Medical School, Hannover, Germany, 5Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany, 6MR Collaborations North East, Siemens Healthineers, Boston, MA, United States, 7Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada, 8Medical Imaging, University of Toronto, Toronto, ON, Canada, 9Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada, 10Neurology, The Hospital for Sick Children, Toronto, ON, Canada

MRI of the neonatal pulmonary system can be a useful tool for the clinical evaluation of lung structure and function without ionizing radiation. Despite this, the inherent challenges associated with MRI of the lung make this difficult. This works demonstrates the feasibility of structural and functional imaging of the neonatal lung without exogenous contrast using a clinical whole-body 3T system with standard coils in neonates without any cardiorespiratory history. The imaging protocol includes T1-weighted, T2-weighted, and ultrashort echo time (UTE) imaging for structural imaging as well as novel free-breathing Phase-Resolved Function Lung (PREFUL) MRI for ventilation/perfusion imaging.

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