Abstract #0428

Feasibility of Structural and Phase-Resolved Functional Lung (PREFUL) MRI in Free-Breathing Neonates

Brandon Zanette¹, Samal Munidasa^1,2, Marcus J Couch¹, Elaine Stirrat¹, Eric Schrauben¹, Robert Grimm³, Andreas Voskrebenzev^4,5, Jens Vogel-Claussen^4,5, Ravi Seethamraju⁶, Christopher K Macgowan^1,2, Mary-Louise C Greer^7,8, Emily Tam^9,10, and Giles Santyr^1,2

¹Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³MR Predevelopment, Siemens Healthcare, Erlangen, Germany, ⁴Diagnostic and Intervetional Radiology, Hannover Medical School, Hannover, Germany, ⁵Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany, ⁶MR Collaborations North East, Siemens Healthineers, Boston, MA, United States, ⁷Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada, ⁸Medical Imaging, University of Toronto, Toronto, ON, Canada, ⁹Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada, ¹⁰Neurology, The Hospital for Sick Children, Toronto, ON, Canada

MRI of the neonatal pulmonary system can be a useful tool for the clinical evaluation of lung structure and function without ionizing radiation. Despite this, the inherent challenges associated with MRI of the lung make this difficult. This works demonstrates the feasibility of structural and functional imaging of the neonatal lung without exogenous contrast using a clinical whole-body 3T system with standard coils in neonates without any cardiorespiratory history. The imaging protocol includes T1-weighted, T2-weighted, and ultrashort echo time (UTE) imaging for structural imaging as well as novel free-breathing Phase-Resolved Function Lung (PREFUL) MRI for ventilation/perfusion imaging.

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