Abstract #0436

Volume-controlled 19F MR imaging of fluorinated gas wash-in

Arnd Jonathan Obert^1,2, Marcel Gutberlet^1,2, Agilo Luitger Kern^1,2, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany

Since Perfluoropropane is highly inert, and can be mixed with oxygen, patients can inhale up to 30 liters of gas during one examination without a significant physiological impact. This enables detailed measurements of gas wash-in dynamics using ¹⁹F magnetic resonance imaging. In this work, an experimental setup for volume-controlled imaging of multiple breath-holds is realized using a pneumotachometer and pneumatic valves as well as MR triggering. In three healthy volunteers, the stability of the breathing volumes and the positions of the diaphragm, as well as the standard deviation of wash-in times, were analyzed comparing volume-controlled to non-controlled scans.

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